NewPublished in the Journal of Neurosurgery

The vision layer for healthcare.

We build AI that sees and understands the physical work of medicine — making surgery and cell therapy radically more efficient.

Now building: spatial intelligence for the OR · Explore →
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Optimization Through AI Vision Systems

We deploy AI vision to remove waste from healthcare

Program 01 · Surgical vision · OR-SPD platform

Every surgical instrument, understood.

01 — See

Every instrument, recognized. No tags.

Our AI classifies every instrument on the tray, straight from the camera — no barcodes or RFID tags on thousands of tools.

02 — Verify

Trays checked before they reach the OR.

At the sterile processing packing station, instrument verification catches missing or wrong instruments before a tray is sent.

~10%of trays packed in unautomated SPDs are returned for re-processing or correction
03 — Optimize

Leaner trays. Faster turnover.

Our AI flags redundant instruments and recommends optimized sets. Each additional tray adds 3 minutes to turnover.

60%fewer instruments on a TLIF tray (100 → 40) at Thomas Jefferson University Hospital
OR table · live segmentation
Instrument tray with each instrument identified by AI
SPD packing · tray verification

Traction

Validated in the clinic. Published in the literature.

60%

reduction in instrument burden on a neurosurgical tray

8 min

OR turnover time saved per case

>6×

first-year return on investment

Academic partners Thomas Jefferson University University College London Babraham Research Campus

Program 02 · Spatial intelligence

From the tray to the whole operating room.

Today our AI sees every instrument on the tray. Now we're teaching it to understand the entire room.

01 — Observe

Vision in live surgery.

We capture live cases on video, and our AI turns them into instrument and turnover data.

02 — Reconstruct

A real operating room, rebuilt in 3D.

Captured on site as a digital twin of around six million Gaussian splats — every table, cart and monitor, explorable from any angle.

03 — Connect

Sterile processing and the OR, in one loop.

Next, SPD Sentinel connects sterile processing and the OR — following every tray and instrument from packing, to the case, and back again, so each case makes the next tray leaner.

A camera rig recording a live surgical case for AI analysis, with the surgical team and navigation screens behind it
Live case · video capture
Operating room rendered from Appraiseye's 3D digital twin: wide view from the other side
Operating room rendered from Appraiseye's 3D digital twin: beside the table
Digital twin · real capture
6M Gaussian splats
Concept · in development
SPD Sentinel
OR table

Program 03 · AI biomanufacturing · Bodhi

Automating the manufacture of living medicines.

01 — Watch

AI-guided microscopy.

Real-time cell culture monitoring, with full visual access for AI-driven quality control.

02 — Automate

A closed-system incubator.

Concentric roller bottles, each with its own programmable microenvironment — reducing labour and variability in scaled-out 2D workflows.

03 — Scale

Adherent production that mirrors the lab.

An adherent 2D platform that follows the discovery SOP — high batch comparability and low early-phase capex, for the segment bioreactors don't serve.

Team

Medicine, AI, and cell & gene therapy under one roof.

Rupert Smit

Rupert Smit, MD

CEO & Co-Founder
Emil Swanepoel

Emil Swanepoel

CTO & Co-Founder
Alwyn Smit

Alwyn Smit

COO & Co-Founder
Carol Ke

Carol Ke, PhD

Chief Scientific Officer
Aria Mahtabfar

Aria Mahtabfar, MD

Director, Clinical Strategy
Morgan Schilling

Morgan Schilling

Director, Medical Sales
Alexandria Bilder

Alexandria Bilder

Advisor
Careers at Appraiseye →

Contact

The physical world of medicine is AI's next frontier.

Investors, hospitals, CGT manufacturers and academic partners — we'd like to hear from you.

HQPhiladelphia, PA, USA
R&DBabraham Research Campus, Cambridge, UK